Again, so used to other giant talking mice in his world, Mickey looks around once more just in case. But when Crowley asks the VERY RUDE "how are you even real" question, Mickey just smiles - apparently, he's a little used to the question, strange as it is.

"I'm just as real as you and everyone else here." He replied calmly. "But I get why you're surprised. All these human-looking people keep surprising me too... we don't have any of them in my home."